CCR-10-1689_Revised_MS Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors
نویسندگان
چکیده
Affiliation of authors: 1 Department of General Pathology, University Hospital Heidelberg, INF 220/221, 69120 Heidelberg, Germany 2 Department of Pathology, University Hospital Erlangen, Krankenhausstraße 12, 91054 Erlangen, Germany 3 Department of Thoracic Surgery, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg, Germany 4 Medical Oncology Branch, National Cancer Institute, 10 Centre Dr, Bethesda, MD 20892, USA 5 Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
منابع مشابه
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors.
PURPOSE The underlying molecular mechanisms of thymic epithelial malignancies (TEMs) are poorly understood. Consequently, there is a lack of efficacious targeted therapies and patient prognosis remains dismal, particularly for advanced TEMs. We sought to investigate protumorigenic mechanism relevant to this understudied cancer. EXPERIMENTAL DESIGN Recently established cell lines derived from ...
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